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Ozonia 10 ® Crema

Ozonia 10 ® Crema
Skin cream with 10% of highly ozonized sunflower oil (Ozonia3000), manufactured exclusively by Innovares.
INFORMATION RESERVED TO THE SANITARY OPERATOR
Skin cream with 10% of highly ozonized sunflower oil (Ozonia3000), manufactured exclusively by Innovares.
Its soothing action helps reduce inflammation, improve the metabolic state of tissues and mucous membranes, as well as prevent and control infection. These effects are properties assigned to Ozonia3000 and account for its multi-purpose use.

Ozonia 10 Cream
Oil-in-water emulsion
Packaging: 35 mL tube
Retail price in Italy: € 14.90

FUNCTIONAL ACTIVE INGREDIENTS
Cream based on 10% of Ozonia 3000®.

INDICATIONS AS ADJUVANT FOR SKIN CARE
Ozonia 10’s target is damaged skin.
Ozonia 10 is a biostimulating skin cream.
Ozonia 10 has a balanced proportion of Ozonia3000 that is appropriate to meet the goals for which the cream has been designed: acceleration of the skin repair process in general and disinfection without cytotoxicity or irritation (specific tests have been carried out).

Its soothing action helps reduce inflammation and improve the metabolic state of tissues, with increased expression of endogenous growth factors, increased antioxidant enzyme activity in cells, and management of mixed infections. These effects are properties assigned to quality ozonized oil (Ozonia3000).

It also plays an important role in regulating tissue perfusion (microcirculation). Its anti-inflammatory and anti-edema activity is also known.
Ozonia 10 helps activate and accelerate epidermis and mucous membrane regeneration and repair in a variety of skin, wound care, and procto-gynecological conditions.

Applying Ozonia 10 to the wounds tends to speed up the repair process, increase the average number of fibroblasts, increase the average number of blood vessels, and make the skin tissue more organized and moisturized.

Abrasions, erosions, grazes, deepithelialization, post-surgical wounds, skin ulcers, either cleaned and debrided or in the presence of contamination and colonization with moderate exudates, where the “occlusivity” factor is not required. Other conditions include peristomal skin change, dermatological conditions requiring deep cleansing and prevention-control of infections (psoriasis, impetigo, ringworm, acne, seborrheic dermatitis, atopic dermatitis, neurodermatitis, post-peeling, post-laser, post-cryotherapy, palmoplantar keratoderma, intertrigo, burns, etc.), open surgical wounds (post-surgical pilonidal cysts, fistulotomy, Milligan Morgan hemorrhoidectomy, residual cavities after stoma closure, etc.). Urogynecological conditions include vulvovaginitis, balanoposthitis, and post-surgical lesions. Proctological conditions include hemorrhoids and anal fissures.

It is indicated for damaged skin and mucous membranes, where the “occlusivity” factor is not required. The antiseptic action of the preparation makes it possible to administer it directly to the injured tissue, after the regular cleansing and debridement procedures.

The stability and standardization in terms of Ozone loaded determine the efficacy of the ozonized oil.

Table of microbial reduction rate (%) obtained with Ozonia10 on different microorganisms
Time (h) Bacteria       Yeasts Molds Protozoa Fungi
  E. coli Pse. aeruginosa Pro. mirabilis Staph. aureus Cand. Albic. Asp. niger Trichom. Trichophyton m.
2 91.25 93.91 92.94 91.07 86.00 87.5 0.00 0.00
4 90.63 95.65 94.12 96.43 95.00 96.42 36.00 0.00
24 99.83 100.00 99.83 99.93 99.64 99.95 90.00 28.00
48 99.94 100.00 99.94 100.00 99.99 99.99 98.00 94.80
7 days 100.00 100.00 100.00 100.00 100.00 100.00 100.00 99.99
Initial inoculum 1.6x106 2.3x106 1.7x106 2.8x106 1.0x105 1.2x105 1.0x105 1.0x105
Linear Regression Report/D-Value Method
University of Ferrara – Department of Experimental and Diagnostic Medicine
Microbiology Unit – Ferrara
Ferrara, March-June 2010

PROPERTIES OF OZONE

BACTERICIDAL: against Staphylococcus Aureus, Pseudomonas Aeruginosa, Staphylococcus Epidermidis, Salmonella Typhimurium, Streptococcus Pyogenes, Escherichia Coli, Proteus Mirabilis, and Gardenella vaginalis.
FUNGICIDAL: against Candida Albicans.
PROTOZOICIDAL: against Trichomonas Vaginalis.
VIRUSTATIC: against Herpes Simplex (labialis, genitalis), Herpes Zoster, Cytomegalovirus, Parvovirus, and Papilloma Virus.
ANESTHETIC and ANTIPHLOGISTIC: reversible oxidation of nociceptive neurofibrils, inhibition of prostaglandin cascade, and antithrombotic action improving the microcirculation.
WOUND HEALING: stimulation of granulation for the mobilization of fibroblasts, oxidation and degradation of toxic necrotic organic material that obstructs wound healing, and stimulation of neoangiogenesis.

DOSAGE AND INSTRUCTIONS FOR USE
One to 3 times a day or at least once every 2 days, even in combination with secondary dressings to manage the lesion in the event of skin ulcer.

SIDE EFFECTS
The product has no side effects except for a warm or slight burning sensation in the beginning, when it comes in contact with the lesion. No hypersensitivity or allergic reactions have been reported; however, if any excessive itching or burning occurs, you should discontinue therapy and speak with a Doctor.

STORAGE
In order to preserve the “active ingredient” load and the cream efficacy, it is preferable not to expose it to long-term temperatures above 23°C. During the hot season, it is preferable to keep the product in a refrigerator at a temperature of 2°-8°C.

PRODUCT WARRANTIES, QUALITY REQUIREMENTS, AND CHARACTERISTICS
OZONIA 10 has proven to be a non-irritating product (assessment of irritancy through occlusive patch tests).
Ozone is a gas with a pungent odor that has been adequately mitigated in the product thanks to a sophisticated manufacturing method: it is, therefore, a sign of the active ingredient’s authenticity and efficacy and it is usually well tolerated.